Contraindicated (one)pentobarbital will reduce the extent or impact of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is chargeable for the formation and elimination of cariprazine's Lively metabolites.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabol